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Comorbidities and Selection of DMTs


Activity Info

Using a case example and a short, summary article, Dr. Joseph Berger describes the considerations clinicians and patients must make regarding comorbidities when selecting DMTs.

CE Information

Activity Title

Comorbidities and Selection of DMTs


Multiple Sclerosis

Accreditation Type

AMA PRA Category 1 Credit(s)™, Nurse CE, ACPE

Release Date

May 14, 2021

Expiration Date

May 13, 2022

Estimated Time to Complete Activity

60 minutes


Upon completion of the activity, participants should be able to:

  • Recognize the significance of MS phenotypes, and characteristic features, with an emphasis on progressive disease
  • Apply a more targeted approach to the treatment of MS when selecting therapy

Joseph R. Berger, MD, FACP, FAAN, FANA
Professor of Neurology and Associate Chief of the Multiple Sclerosis Division
Perelman School of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania


  1. There are no fees for participating in and receiving credit for this activity.
  2. Review the activity objectives and CME/CE information.
  3. Complete the CME/CE activity.
  4. Complete the online posttest. A score of at least 75% is required to successfully complete this activity. The participant may take the test until successfully passed.
  5. Complete the CME/CE evaluation/attestation form, which provides each participant with the opportunity to comment on how participating in the activity will affect their professional practice; the quality of the instructional process; the perception of enhanced professional effectiveness; the perception of commercial bias; and his/her views on future educational needs.
  6. Credit documentation/reporting:
    • If you are requesting AMA PRA Category 1 Credits™, Nursing CE, or a certificate of participation—your CME/CE certificate will be available for download.
    • If you are requesting ACPE pharmacy credit—your CE credits will be submitted electronically to the CPE Monitor



In support of improving patient care, this activity has been planned and implemented by the Consortium of Multiple Sclerosis Centers (CMSC) and The France Foundation. CMSC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

This activity was developed for neurologists, nursing professionals, and other members of the health care team who care for patients with MS.

In light of the recent, rapid pace of pharmacotherapy development and availability in MS, it becomes especially crucial that neurologists and other health care providers are well equipped to evaluate and apply data on the latest therapies to the complex task of initial and subsequent treatment selection. While the focus of the current clinical and research climate is often on newer therapies with innovative mechanisms, it remains important that neurologists and others remain up-to-date on data and options pertaining to established therapies as well. It is equally essential that clinicians are equipped with evidence-based knowledge and skills that facilitate timely and accurate evaluations of disease activity and progression, both clinically and radiologically, as a means of understanding prognosis and optimal treatment selection.

The CMSC designates this activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses: The CMSC designates this enduring material for 1.0 contact hours of continuing education (1.0 in the area of pharmacology).

Pharmacists: This knowledge-based activity (UAN JA4008165-9999-21-006-H01-P) qualifies for 1.0 contact hour (.1 CEUs) of continuing pharmacy education credit. Your CE credits will be submitted electronically to the CPE Monitor. CE providers must upload participant information within 60 days from the date the participant completed the activity. Please submit all evaluations and credit requests no later than 30 days after you complete this activity to ensure your credit fulfillment, as CE credit cannot be awarded past 60 days from the activity date.

Certificate of Completion: A Certificate of Completion may be given upon completion of course requirements enabling you to register your credit with the appropriate licensing boards or associations. You may apply for other accreditations using the procedure established by the specific organization.

The Consortium of Multiple Sclerosis Centers (CMSC) and The France Foundation (TFF) require CME/CE faculty (speakers) to disclose when products or procedures being discussed are off-label, unlabeled, experimental, and/or investigational, and any limitations on the information that is presented, such as data that are preliminary, or that represent ongoing research, interim analyses, and/or unsupported opinion. Faculty in this activity may discuss information about pharmaceutical agents that is outside of US Food and Drug Administration approved labeling. This information is intended solely for continuing medical education and is not intended to promote off-label use of these medications. CMSC and TFF do not recommend the use of any agent outside of the labeled indications. If you have questions, contact the Medical Affairs Department of the manufacturer for the most recent prescribing information.

In accordance with the ACCME Standards for Commercial Support, the Consortium of Multiple Sclerosis Centers (CMSC) and The France Foundation (TFF) require that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. CMSC and TFF resolve all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all their educational programs. Furthermore, CMSC and TFF seek to verify that all scientific research referred to, reported, or used in a CME/CE activity conforms to the generally accepted standards of experimental design, data collection, and analysis. CMSC and TFF are committed to providing learners with high-quality CME/CE activities that promote improvements in health care and not those of a commercial interest.

Activity Staff Disclosures
The planners, reviewers, editors, staff, continuing education committee, or other members at CMSC who control content have no relevant financial relationships to disclose.

The planners, reviewers, editors, staff, CME committee, or other members at The France Foundation who control content have no relevant financial relationships to disclose.

Faculty Disclosures–Activity Faculty
The following faculty report that they have relevant financial relationships to disclose:

  • Joseph R. Berger, MD, FACP, FAAN, FANA, reports that he has done consulting for Amgen, Biogen, BMS/Celgene, Dr. Reddy's Laboratories, Encycle, Excision Bio, Genentech/Roche, Genzyme, Mapi, Merch, Millennium/Takeda, Morphic, Novartis, Serono, and Shire

This activity is supported by an educational grant from Biogen and Sanofi Genzyme.

Consortium of Multiple Sclerosis Centers and The France Foundation present this information for educational purposes only. The content is provided solely by faculty who have been selected because of recognized expertise in their field. Participants have the professional responsibility to ensure that products are prescribed and used appropriately on the basis of their own clinical judgment and accepted standards of care. The France Foundation, Consortium of Multiple Sclerosis Centers, and the commercial supporter(s) assume no liability for the information herein.

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If you have questions about this activity, please contact The France Foundation at 860-434-1650 or info@francefoundation.com.